Perpustakaan Digital

This Special Issue of Current Issues in Molecular Biology explored the current knowledge and innovative concepts regarding preclinical and clinical research into stroke mechanisms, prevention, and treatment and provided a critical overview of the underlying factors involved in stroke-related brain injury, especially the role of cell signaling in excitotoxicity, inflammation, apoptosis, and the newly described types of cell death such as ferroptosis and their potential treatment. Gene and protein expression profiles after stroke and neurogenesis, angiogenesis, and neuroplasticity are other important features in stroke and should lead to the better understanding of the pathophysiology of acute stroke.

The following Special Issue on the “Prevention, Diagnosis and Treatments of Early-Stage NSCLC: New Advances and Future Prospective” forms a collection of articles showcasing the latest scientific progress in this field, focusing particular attention on minimally invasive techniques such as video-assisted thoracic surgery (VATS) and robotic-assisted thoracic surgery (RATS) compared to open surgery both for early and long-term outcomes in addition to the role of sublobar resection for the treatment of early-stage NSCLC compared to lobectomy. Moreover, we also focus on the importance of recently identified potential biomarkers such as TLR expression to be used for future prognostic purposes in NSCLC and the importance of enhancing immune response in NSCLC patients with the use of the 13-valent pneumococcal conjugate vaccine (PCV13).

This Special Issue delves into the realm of geographic information systems (GIS) and their pivotal role in fostering green development. Featuring a collection of rigorous research articles authored by esteemed experts in the field, this compilation offers insights into the applications of GIS within the domain of sustainable development. These contributions underscore GIS as an indispensable tool in sustainable development endeavors. We hope that these contributions shed light on the ability of GIS to inform decision-making processes, facilitate renewable energy planning, and contribute to disaster management strategies. The scientific rigor and advancements showcased in this Special Issue can provide a comprehensive understanding of how GIS is steering progress in green development. Related Books Application of Remote Sensing and GIS for Promoting Sustainable Geoenvironment Environmental & Earth Sciences Geographic Information Systems and Cartography for a Sustainable World Compute

The present reprint contains the 11 papers that were accepted and published in the Special Issue “Applied and Computational Mathematics for Digital Environments” of the MDPI Mathematics journal. The topics of interest include, among others, scientific research, applied tasks, and problems in the following areas: The construction of mathematical and information models of intelligent computer systems for monitoring and controlling the parameters of digital environments; The development of intelligent optimization algorithms that search for optimal parameter values of mathematical and information models in digital environments; Software and mathematical technologies in the implementation of intelligent monitoring and computer control of the parameters of digital environments; The development and application of mathematical and information models, machine learning methods, and artificial intelligence for the analysis and processing of big data in digital environments. I hope that this

Technologies to harvest marine renewable energies (MREs) are at a pre-commercial stage, and significant R&D progress is still required in order to improve their competitiveness. Therefore, hybridization presents a significant potential, as it fosters synergies among the different harvesting technologies and resources. In the scope of this Special Issue, hybridization is understood in three different manners: (i) combination of technologies to harvest different MREs (e.g., wave energy converters combined with wind turbines); (ii) combination of different working principles to harvest the same resource (e.g., oscillating water column with an overtopping device to harvest wave energy); or (iii) integration of harvesting technologies in multifunctional platforms and structures (e.g., integration of wave energy converters in breakwaters). This Special Issue presents cutting-edge research on the development and testing of hybrid technologies for harvesting MREs and intends to inform intere

Coastal ecosystems are dynamic, complex, and often fragile transition environments between land and oceans. They are exclusive habitats for a broad range of living organisms, functioning as havens for biodiversity and providing several important ecological services that link terrestrial, freshwater, and marine environments. Humans living in coastal zones have been strongly dependent on these ecosystems as a source of food, physical protection against storms and advancing sea, and a range of human activities that generate economic income. Notwithstanding, the intensification of human activities in coastal areas of the recent decades, as well as the global climatic changes and coastal erosion processes of the present, have had detrimental impacts on these environments. Maintaining the structural and functional integrity of these environments and recovering an ecological balance or mitigating disturbances in systems under the influence of such stressors are complex tasks, only possible t

The book starts with the editors’ preface summarizing the contributions of each of the following thirteen articles dealing with chemical and pharmacological aspects of the molecular modulators of the oxidative stress in regard to various therapeutic approaches in cardiovascular and neurodegenerative diseases, cancer, and diabetes. The seven articles present data from original research studies enlightening the roles and mechanisms of action of small molecular weight compounds (natural and synthetic; ascorbic acid/vitamin C, deferoxamine, N-acetylcysteine, MitoVitE, α-tocopherol, trolox, and ezetimibe) or proteins (SIRT3) in modulation of oxidative stress. In the six review papers, the authors present and discuss the possible therapeutic potential of novel approaches and compounds that are promising and deserve further investigation, in modulation of oxidative stress. Related Books Oxidative Stress Modulators and Functional Foods Medicine & Pharmacology Cellular and Molecular Mechanisms

Colloids, such as emulsions, foams, sols, and gels, play an integral role in living organisms, the natural environment, resource extraction, pharmaceuticals, cleaning products, processing industries, and basically, in almost all aspects of our everyday life. To a large extent, colloid stability and functionality are determined by the properties of interfaces between dispersed and continuous phases and by the surface forces acting at micro- and nanoscale levels. It is the amphiphilic molecules that are capable of altering colloidal system properties, thus changing the overall system behavior. This is why a comprehensive understanding of the amphiphile molecular structure and the respective interactions taking place at the interfaces ensures effective control over colloidal system properties. The contributions included in this Reprint highlight the relation between amphiphile molecular structure, self-assembly in solutions, molecular arrangements at interfaces, specific interactions at micro- and nanoscales, and the properties displayed by the colloidal systems. The included research spans from fundamental studies on the physicochemical behavior of colloidal systems to the design of innovative solutions for practical applications.

This Reprint will consider developments in advanced  cold spray technology, exploring its innovative applications and transformative impacts across various industries. Cold spray technology, with its ability to deposit coatings and fabricate parts without melting the feedstock, offers unique advantages such as minimal thermal distortion, high deposition rates, and the ability to work with a wide range of materials. In this Reprint , we present a collection of cutting-edge studies and expert insights that showcase the latest advancements in cold spray techniques, equipment, and applications. This compilation includes studies on the optimization of process parameters, development of new materials, and enhancement of coating properties to meet the demanding requirements of the aerospace, automotive, and biomedical sectors, among others. By highlighting breakthroughs in surface engineering, the repair and restoration of components, and additive manufacturing, we will  improve our  understanding of the current state and future potential of cold spray technology.

This reprint includes a total of 10 articles aiming to provide recent or overall study results to investigate the effects of dioxins on human health, focusing on children and adults exposed to historical and/or present pollution in Vietnam. In particular, epidemiological studies of Vietnamese children living in hot spots of dioxin contamination were performed after more than 40 years since the Vietnam War ended, but significantly, high exposure levels and health effects were still significant in all articles. In addition, the research methods of these articles are innovative and use advanced technologies such as MRI imaging analysis and eye-tracking. Another original article is a study showing the usefulness of coupling environmental whole-mixture toxicity screening with unbiased RNA-seq using biological responses in Danio rerio (zebrafish) in contaminated aquatic environments. Although there are very few publications that show the study results to investigate cancer incidence in the

Discover the complexities of pediatric orthopedics in this comprehensive reprint book. Pediatric orthopedics present unique challenges in diagnosis and treatment, necessitating the expertise of skilled specialists. Congenital, developmental, and acquired orthopedic issues, including infectious, neuromuscular, nutritional, neoplastic, psychogenic, and traumatic conditions, are explored. With a focus on evidence-based recommendations, this book addresses the management of orthopedic deformities in children by considering different clinical scenarios. From upper and lower limb injuries to severe trauma, readers will gain insights into decision-making processes for reconstruction or amputation. As a valuable resource for orthopedic surgeons, pediatricians, and healthcare professionals, this reprint fills knowledge gaps to optimize patient care. Related Books Pediatric Fractures Medicine & Pharmacology Pediatric Fractures—Volume II Medicine & Pharmacology Acute Trauma and Trauma Care in

The Special Issue "In Vitro and In Vivo Models of Colorectal Cancer for Clinical Application", edited by Marta Baiocchi and Ann Zeuner for Cancers, collects original research papers and reviews, depicting the current state and the perspectives of CRC models for preclinical and translational research. Original research papers published in this issue focus on some of the hottest topics in CRC research, such as circulating tumor cells, epigenetic regulation of stemness states, new therapeutic targets, molecular CRC classification and experimental CRC models such as organoids and PDXs. Additionally, four reviews on CRC stem cells, immunotherapy and drug discovery provide an updated viewpoint on key topics linking benchtop to bedside research in CRC. Related Books Molecular Biology of Colorectal Cancers Biology & Life Sciences ... Colorectal Cancers: From Present Problems to Future Solutions Biology & Life Sciences Therapeutic Landscapes in Colorectal Carcinoma Biology & Life Sciences Cl

This book presents the latest solutions in fuel cell (FC) and renewable energy implementation in mobile and stationary applications. The implementation of advanced energy management and optimization strategies are detailed for fuel cell and renewable microgrids, and for the multi-FC stack architecture of FC/electric vehicles to enhance the reliability of these systems and to reduce the costs related to energy production and maintenance. Cyber-security methods based on blockchain technology to increase the resilience of FC renewable hybrid microgrids are also presented. Therefore, this book is for all readers interested in these challenging directions of research. Related Books Advanced Modeling, Control, and Optimization Methods in Power Hybrid Systems - 2021 Engineering Efficiency and Sustainability of the Distributed Renewable Hybrid Power Systems Based on the Energy Internet, Blockchain Technology and Smart Contracts Engineering Optimal Control of Hybrid Systems and Renewable Ene

Cardiovascular diseases are the first cause of death worldwide, in which genetic and environmental factors seem to play a determinant role. In fact, several lifestyle (i.e., dietary, physical inactivity) factors and nutritional-related diseases (i.e., obesity, type 2 diabetes) are strongly associated with cardiovascular diseases. Moreover, genome-wide association studies have also identified numerous genomic loci that determine susceptibility to cardiovascular events. Therefore, nutrition and genetics seem to interact in predisposing an individual to cardiovascular diseases. This book provides a presentation of recent advances in knowledge on nutrition, genetics, and cardiovascular disease coming from diverse scientific disciplines. Related Books Nutrition and Cardiovascular Health Biology & Life Sciences The Effect of Diet on Cardiovascular Disease, Heart Disease and Blood Vessels Public Health & Healthcare ... Nutrition, Exercise, and End-of-Life Discussion in the Cardiovascular Fie

This Reprint, entitled “Cadmium and Trace Elements Toxicity,” brings together ten high-quality research articles that advance our understanding of the sources, mechanisms, and health impacts of cadmium and trace element exposure. The contributions span multiple disciplines, from molecular toxicology and environmental monitoring to plant science and risk assessment, providing a comprehensive overview of current research in this critical field. The articles address key topics including novel toxicity mechanisms, biomonitoring approaches, protective strategies, and environmental quality criteria.

Slaughter animals are transported, lairaged and stunned before slaughter. The welfare of animals can be compromised during this period. It is expected that all animals be protected from avoidable sources of disturbance, pain, or suffering during transport, lairage, restraint, stunning, slaughter, or killing. Slaughter animals include horses, ruminants, pigs, poultry, and species of fish. The different aspects involved in handling these animals are described in each chapter.

This Special Issue of the International Journal of Molecular Sciences (IJMS), entitled “Molecular Mechanism in Epithelial-Mesenchymal Transition (EMT) and Fibrosis”, collected 15 original research papers (5 reviews and 10 articles) written by a panel of experts from different countries who highlight recent advances in the EMT process.Navigating the complex field of EMT, this Special Issue introduces the current understanding of the underlying mechanisms of EMT in the evolution and progression of fibrogenesis and discusses potential strategies for attenuating EMT to prevent and/or inhibit fibrosis.Overall, the 15 scientific articles in this Special Issue of the International Journal of Molecular Sciences provide valuable insights into the complex mechanisms governing the EMT process linked to fibrosis and have highlighted the potential of novel therapeutic strategies. In the last few years, the field of EMT has shown considerable promise, and there is still much to be learned. As our

This book explores sustainable urban development, addressing the challenges and opportunities encountered in the 21st century. It addresses topics such as resilience, blockchain architecture, and green roofs, offering insights into urban challenges and opportunities. The research provides innovative strategies and best practices for sustainable, equitable, and resilient urban communities. The collection emphasizes stakeholder integration, community engagement, and the importance of addressing specific challenges faced by vulnerable populations. As a valuable resource for researchers, practitioners, policymakers, and students, this publication aims to foster informed conversations about the future of urban planning and design, and inspire further research and dialogue on sustainable urban development, paving the way for more sustainable urban communities worldwide. Related Books Planning, Development and Management of Sustainable Cities Biology & Life Sciences ... State of the Art an

Graphene is a two-dimensional, one-atom-thick material made entirely of carbon atoms, arranged in a honeycomb lattice. Because of its distinctive mechanical (e.g., high strength and flexibility) and electronic (great electrical and thermal conductivities) properties, graphene is an ideal candidate in myriad applications. Thus, it has just begun to be engineered in electronics, photonics, biomedicine, and polymer-based composites, to name a few. The broad family of graphene nanomaterials (including graphene nanoplatelets, graphene oxide, graphene quantum dots, and many more) go beyond and aim higher than mere single-layer (‘pristine’) graphene, and thus, their potential has sparked the current Special Issue. In it, 18 contributions (comprising 14 research articles and 4 reviews) have portrayed probably the most interesting lines as regards future and tangible uses of graphene derivatives. Ultimately, understanding the properties of the graphene family of nanomaterials is crucial for d

This Special Issue is conceived as a forum for basic, translational, and clinical research related to cell directional motility mechanisms and tumor cell migration. Under such a generic umbrella, basic researchers in biology, systems biology, and other quantitative sciences, as well as in physiology and pharmacology, will have the opportunity to join clinical specialties in medical oncology, biochemistry, immunology, and pathology. Such unique convergence of disciplines will enrich the panorama of a central characteristic of malignant tumors' cell motility. Related Books Molecular Mechanisms of Cancer Development and Metastasis Biology & Life Sciences Metabolic Alterations in Cancer Biology & Life Sciences Biomarkers of Tumor Metastasis and Invasiveness Medicine & Pharmacology Molecules at Play in Cancer Biology & Life Sciences Molecular Biology of Colorectal Cancers Biology & Life Sciences ... The recommendations have been generated using an AI system. About: About MDPI Books Ad

In many parts of the world, freshwater is a subject of frequent and intense large-scale disturbances. Pollution, water withdrawal, alteration of freshwater flows, road construction, aquifer mining, surface water diversion, desertification, wetland drainage, soil erosion in agriculture, deforestation, and dam building have led to some irreversible species losses and severe changes in community compositions of freshwater ecosystems. Pollution represents one of the most relevant impacts on freshwater environments, ranging from surface water bodies—such as springs, streams, rivers, lakes, and intermittent waterbodies—to groundwater and transitional habitats between surface waters and groundwaters. The origins and fates of pollutants are different and depend on various pollutants, including fertilizers with pesticides in agricultural areas, heavy metals, chlorinated organic compounds, and polycyclic aromatic hydrocarbons (PAHs), which are predominantly derived from industrial and urban set

This Special Issue Reprint compiles cutting-edge research on Unmanned Aerial Vehicles (UAVs), highlighting transformative advancements that broaden their capabilities across diverse sectors. Bringing together contributions from researchers, practitioners, and industry experts, this collection fosters interdisciplinary dialogue while delivering rigorous peer-reviewed insights into UAV technology and services. It covers a comprehensive range of critical topics, such as the following: autonomous navigation and control systems (including advanced algorithms for obstacle detection, path planning, and formation flying); innovative sensing/imaging technologies (hyperspectral imaging, LiDAR, thermal imaging for data acquisition); efficient communication/networking solutions (reliable, secure connectivity, network coordination, swarm intelligence for networked UAVs); payload design and service delivery (medical supply transport, infrastructure inspections); energy efficiency research (energy harvesting, optimization algorithms, sustainable power sources); and regulatory/ethical considerations for safe, responsible UAV deployment. Featuring original research articles, reviews, and case studies, this Reprint captures the latest breakthroughs pushing UAV application boundaries. It serves as an invaluable resource for professionals and researchers seeking to keep up to date with industry progress, inspiring further innovation and collaboration to advance UAV technology’s real-world impact.

Robotic control is a system that contributes to the movement of robots. Robotics can be controlled in various ways, such as via manual control, wireless control, semi-autonomously (a mix of fully automatic and wireless control), and fully autonomously (using AI to control movement alone, with the potential option of using manual control). As technological advancements progress, robots and the methods of their control continue to develop and advance. This Special Issue features a collection of 11 excellent research papers published in Actuators, showcasing and discussing new advances in actuators and mechatronic systems for robotics.

Standards can be international, national, regional, or corporate. They cover production and consumption, social responsibility, health and safety, quality management, laboratories, diverse devices, and equipment, to mention the most popular ones. They are the basis for our everyday activities: air, water, and food quality, information security, codes, accounting, reporting, etc. Despite the great number of existing standards, new and improved ones are appearing daily. The standardization process includes development, acceptance, and implementation of new or improved standards. The stakeholders can be companies, standardization institutions, governments, users, interest groups, professionals, and scientists. The international organization for standardization, ISO, has a guidance document on new work with three parts: 1) new standardized areas, 2) new fields of work, and 3) new work item proposals within existing committees. New standards need to be inspected, verified, and their quali